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AKBA is an active triterpenoid compound from the extract of Boswellia serrate and a novel Nrf2 activator.
Refer to
Boswellia serrata Preserves Intestinal Epithelial Barrier from Oxidative and Inflammatory Damage.
Catanzaro D1, Rancan S1, Orso G2, Dall'Acqua S1, Brun P3, Giron MC1, Carrara M1, Castagliuolo I3, Ragazzi E1, Caparrotta L1, Montopoli M1. PLoS One. 2015 May 8;10(5):e0125375. doi: 10.1371/journal.pone.0125375. eCollection 2015.
Aminosalicylates, corticosteroids and immunosuppressants are currently the therapeutic choices in inflammatory bowel diseases (IBD), however, with limited remission and often serious side effects. Meanwhile complementary and alternative medicine (CAM) use is increasing, particularly herbal medicine. Boswellia serrata is a traditional Ayurvedic remedy with anti-inflammatory properties, of interest for its usefulness in IBDs. The mechanism of this pharmacological potential of Boswellia serrata was investigated in colonic epithelial cell monolayers exposed to H2O2 or INF-γ+TNF-α, chosen as in vitro experimental model of intestinal inflammation. The barrier function was evaluated by the transepithelial electrical resistance (TEER) and paracellular permeability assay, and by the tight junction proteins (zonula occludens-1, ZO-1 and occludin) immunofluorescence. The expression of phosphorylated NF-κB and reactive oxygen species (ROS) generation were determined by immunoblot and cytofluorimetric assay, respectively.
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